NIHR/Wellcome Trust
Cambridge Clinical Research Facility

About Us Top

We specialise in supporting researchers, especially those with experimental medicine projects and early phase clinical trials, in adults and children. We are funded by the National Institute for Health Research (NIHR) to provide dedicated facilities to support experimental medicine clinical research. We are one of 19 NIHR Clinical Research Facilities.

We have three units: the NIHR/Wellcome Trust Clinical Research Facility (CRF), an NIHR Clinical Investigation Ward (CIW), and a CRF Satellite unit. Together, these comprise the Addenbrooke's Clinical Research Centre (ACRC) – a safe, well-equipped and professionally staffed research facility.

The facility employs highly trained staff skilled in chemotherapy and monoclonal antibody drug administration, endoscopy procedures and metabolic and physiological measurement. Within the Metabolic Research Area (MRA) we have equipment for DXA, BOD POD, direct/indirect calorimetry and whole body composition measurement.

Facilities For Research Top

Facilities include eleven 24/7 inpatient beds (in the CRF) and seven day-case beds (in the CIW) for interventional treatments. Outpatient and Investigation rooms are available Monday to Friday from 8am – 8pm. We also have a dedicated Play Room to support studies in children.

Facilities are also available for audiology, dietetic interventions, diet manipulations, sample handling and processing, with both university and NHS IT systems, including wifi access.

From first contact, our highly experienced staff can not only support your research but can guide you through any necessary administrative processes - from governance and indemnity issues to best clinical practice and staff education.

We currently support over 220 research studies, with the majority of these studies involving either medium or high-intensity interventions, in both adults and children.

Researchers translating experimental medicine into patient benefits at the CRF

Apply To Use Our Facilities Top

All research undertaken within the ACRC is reviewed by the Scientific Advisory Board (SAB). The membership of the SAB is broad-based to optimise the assessment of any application from a range of diverse disciplines.

Our Director is Professor Krishna Chatterjee and our Head of Clinical operations is Caroline Saunders.

Studies are first assessed in detail for scientific merit by a nominated SAB member, before the board as a whole considers and approves the appropriate allocation of resources for any project. The SAB meets on a monthly basis.

SAB Dates

Submission Meeting date
15 January 2015 05 February 2015
12 February 2015 05 March 2015
12 March 2015 02 April 2015
16 April 2015 07 May 2015
14 May 2015 04 June 2015
11 June 2015 02 July 2015
16 July 2015 06 August 2015
13 August 2015 03 September 2015
10 September 2015 01 October 2015
15 October 2015 05 November 2015
12 November 2015 03 December 2015
17 December 2015 07 January 2016

If you require an application pack or need further information please click or contact;

Click here to download the ACRC Application Form

Click here to download the ACRC User Guidelines (2013)

Click here to download the ACRC Operational Policy

Click here to send an email for further information

Caroline Saunders
(Head of Clinical Operations)
Ext. 01223 596057
Int. x6057

To View Availability For Booking Patients/Participants Top

Please click to view the CRF facility calendar.

Please click to view the CIW facility calendar.

Education Top

Our Education team provides service-specific training and Education for all Addenbrooke's Clinical Research Centre (ACRC) staff and others using the facility. Induction, emergency scenario training, study-specific training, research skills training and clinical skills training – delivered locally and regionally. All nurses joining the unit are provided with induction training.

Kornelia Hathaway is our Education and Training Manager.

Courses providing an introduction for professionals new to working in Clinical Research;

Nationally recognised training and education documents co-authored by ACRC staff;

Patient and Public Involvement (PPI) Top
... research for you, with you

We believe that excellence in research is best achieved by involving and engaging patients and the public in our work, to inform the way we deliver and develop our services, to understand and improve patient experience, to share and learn from our experiences and to work collaborative across organizations where joint activities can add most value. Our priorities are about putting people first in research and supporting activities that enhance meaningful patient and public involvement, engagement and participation.


Our Children's Non-Executive Board was established in 2013 to enable children to have a voice in our service development, to input into the design of generic and study specific patient information and to try out metabolic measurement kit. Membership includes children who have participated in studies on the CRF, children who have never participated in research, parents and members of staff.

Activities and outputs:

Children's Non-Executive Board Video


We regularly hold and take part in local and national open days, public meetings, presentations to: patient groups, local schools, visiting students. We also contribute to local media publications; Matters Magazine - Autumn 2013.
Research related 'good news' stories and 'case studies' are displayed around the unit to share our work with patients and the public.

Forthcoming events (links to):


Many of our patients are recruited into research studies via specific volunteer groups these include:
The Clinical Research Facility healthy volunteer metabolic reference measurement study:

The Cambridge BioResource healthy volunteer and patient panels:

Cambridge NIHR Biomedical Research Centre Patient Panel:

NIHR BioResource: Rare Disease patient and healthy volunteer panels:
NIHR BioResource - How to Join

We also provide meeting room facilities for investigators to hold study specific patient focus group meetings.

Collaboration and sharing best practice

Our PPI leads have established links with local and national groups working collaboratively on many activities, events and initiatives including workshops, conferences, patient groups, staff groups from across the NIHR.

Key local PPI contacts:

NIHR/Wellcome Trust Cambridge Clinical Research Facility